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Chemical burns of the oral mucosa caused by Policresulen: report of a case

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Á¤Á¤¿ì ( Jung Jung-Woo ) - °æºÏ´ëÇб³ Ä¡ÀÇÇÐÀü¹®´ëÇпø ±¸°­³»°úÇб³½Ç
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Á¤À籤 ( Jung Jae-Kwang ) - °æºÏ´ëÇб³ Ä¡ÀÇÇÐÀü¹®´ëÇпø ±¸°­³»°úÇб³½Ç
ÃÖÀç°© ( Choi Jae-Kap ) - °æºÏ´ëÇб³ Ä¡ÀÇÇÐÀü¹®´ëÇпø ±¸°­³»°úÇб³½Ç

Abstract

±¸°­Á¡¸·ÀÇ È­ÇÐÈ­»óÀº ´Ù¾çÇÑ È­ÇÐÁ¦Ç°°úÀÇ Á¢ÃË¿¡ ÀÇÇØ ÀϾ ¼ö ÀÖÀ¸¸ç ±¹¼Ò Á¡¸·¿°, °¢È­¼º ¹é»öº´¼Ò, ÃâÇ÷, ÅëÁõ¼º Á¶Á÷ Ç¥¸é µî°ú °°Àº ÀÓ»óÀû Ư¡À» ³ªÅ¸³½´Ù. Policresulen(¾Ëº¸Ä¥¢ç)Àº »êºÎÀΰú, ÇǺΰú, À̺ñÀÎÈÄ°ú ¿µ¿ª¿¡¼­ Á¡¸·À̳ª ÇǺÎÀÇ ¼Òµ¶ ¹× ÁöÇ÷ ¸ñÀûÀ¸·Î »ç¿ëµÇ´Â ÀϹÝÀǾàÇ°ÀÌ´Ù. pH 0.6ÀÇ °­»ê¼ºÀ» ¶ì°í À־ °­·ÂÇÑ ºÎ½ÄÁ¦·Î ÀÛ¿ëÇÒ ¼ö ÀÖÀ¸¸ç ±¸°­Á¡¸·¿¡ Á¢Ã赃 °æ¿ì ±«»ç³ª È­ÇÐÈ­»ó°ú °°Àº ºÎÀÛ¿ëÀ» ³ªÅ¸³¾ ¼ö Àֱ⠶§¹®¿¡ »ç¿ë»ó ¼¼½ÉÇÑ ÁÖÀǸ¦ ¿äÇÑ´Ù. 56¼¼ ¿©ÀÚ È¯ÀÚ°¡ ÀÔ¼úÀÇ ±Ë¾ç°ú ºÎÁ¾ ¹× ¿°Áõ¼º »ïÃâ¹°À» ÁÖ¼Ò·Î ±¸°­³»°ú¿¡ ³»¿øÇÏ¿´´Ù. ÀÌ È¯ÀÚ´Â ¾à 10³â ÀüºÎÅÍ Çú¹Ù´ÃÀÌ °¡²û ¹ß»ýÇÏ¿´À¸¸ç ±×·± °æ¿ì¿¡ ¾Ëº¸Ä¥¢çÀ» Á¾Á¾ »ç¿ëÇß¾ú´Ù°í ÇÏ¿´´Ù. ÃÖ±Ù¿¡´Â Çô¿Í ÀÔ¼úÀÇ ÅëÁõ ¶§¹®¿¡ ¾Ëº¸Ä¥¢çÀ» Çô¿Í ÀÔ¼ú¿¡ ±¤¹üÀ§ÇÏ°Ô ¿©·¯ Â÷·Ê µµÆ÷ÇÑ ÀûÀÌ ÀÖ´Ù°í ÇÏ¿´´Ù. ÀÓ»ó°Ë»ç»ó ÇôÀÇ Àü¹æ 1/2 ºÎÀ§¿¡¼­ È«¹Ý¼º ¹Ì¶õ ¹× ¿°Áõ¼º »ïÃâ¹°ÀÌ °üÂûµÇ¾ú°í »ó, Çϼø¿¡ ÃâÇ÷¼º °¡ÇÇ ¹× ±Ë¾çÀÌ Çü¼ºµÇ¾î ÀÖ¾ú´Ù. ¾Ëº¸Ä¥ »ç¿ëÀ» Áß´ÜÇÏ°Ô ÇÑ ÈÄ ±¸¼øºÎ¿¡ ½ºÅ×·ÎÀÌµå ¿¬°í µµÆ÷ ¹× ½ºÅ×·ÎÀÌµå ±¸°­ °¡±Û¾× »ç¿ë ÈÄ 1ÁÖÀÏ ¸¸¿¡ º´¼Ò´Â ÇöÀúÈ÷ ÁÙ¾îµé¾úÀ¸¸ç 2ÁÖ ÈÄ ¿ÏÄ¡µÇ¾ú´Ù. º» Áõ·Ê¸¦ ÅëÇؼ­ ÀϹÝÀǾàÇ°À¸·Î ½±°Ô Á¢ÇÒ ¼ö ÀÖ´Â Policresulen(¾Ëº¸Ä¥¢ç)ÀÇ ¿À¿ëÀ¸·Î ÀÎÇÑ ±¸°­Á¡¸·ÀÇ ÃâÇ÷¼º ±Ë¾çÀÇ ¹ß»ý ¾ç»ó ¹× Ä¡·á°úÁ¤À» ¼Ò°³ÇÏ¿´À¸¸ç, ±¸°­Á¡¸·¿¡¼­ ¹ß»ýÇÏ´Â È­ÇÐÈ­»ó¿¡ ´ëÇØ °íÂûÇÏ¿´´Ù.

Chemical burn on the oral mucosa is caused by contact with various chemical products and manifests with localized mucositis, keratotic white lesions, bleeding, and painful tissue surface due to the coagulation of the tissue. Policresulen (Albothyl¢ç) is a topical antiseptic, commonly used over-the-counter drug for vaginitis, thrush and stomatitis. This drug is highly acidic with pH 0.6, and can act as a strong corrosive agent to oral mucosa. When inadvertently used in oral cavity, it may cause chemical burns of oral mucosa, resulting necrosis and bleeding surface resembling to erythema multifome. A 56 years old female patient presented with the chief complaints of painful ulcerations on the tongue, the upper and lower lips. On intraoral examination, an erythromatous, erosive or ulcerative surface covered with inflammatory exudates or bleeding crust is observed on the anterior half of the tongue and the upper and lower lips. She has occasionally applied the policresulen solution topically on the tongue to relieve pain from recurrent focal glossitis for about 10 years. In this time she applied it broadly and repeatedly to the tongue, the upper and lower lips for the purpose of pain relief by herself without instruction by physician or dentist. After cessation of policresulen application, the oral mucosa was rapidly recovered with use of topical steroids. In 2 weeks the lesions subsided completely. In summary, inadvertent use of Albothyl¢ç on oral mucosa may result in chemical burn, causing mucosal erosion, ulceration and inflammation. It can be recovered by topical use of corticosteroid for 2 weeks after cessation of using Albothyl¢ç.

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Policresulen; oral mucosa; chemical burns; topical steroids

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